Sequential Organ Failure Assessment (SOFA-1)

SOFA-1 summarizes dysfunction across six organ systems in adults in the ICU; use the worst values from the documented 24-hour interval.

SOFA-1 (original 1996 specification) · Adults in an ICU; use the worst values recorded during the documented 24-hour interval.

Clinical parameters

Respiratory

Oxygenation method

P/F ratio (PaO₂ available)S/F ratio (PaO₂ unavailable)

Use PaO₂/FiO₂ when PaO₂ is available. S/F is an imputed alternative.

Required

FiO₂ as a fractionfraction

RequiredAllowed: 0.01–1 fraction

Respiratory support present

NoYes

Required

Coagulation and liver

Platelet count (×10⁹/L)

RequiredAllowed: ≥ 0

Total bilirubin

RequiredAllowed: ≥ 0 mg/dL

Cardiovascular

Mean arterial pressure (MAP)mmHg

RequiredAllowed: ≥ 0 mmHg

Qualifying vasoactive support

No qualifying vasoactive agentQualifying vasoactive agent present

Enter only agents administered for at least 1 hour; leave unused agents blank.

Required

Neurology and renal

Glasgow Coma Scale (GCS)

RequiredAllowed: 3–15

Serum creatinine

RequiredAllowed: ≥ 0 mg/dL

Urine output over 24 hoursmL/day

Optional; when entered, the more severe renal category is used.

OptionalAllowed: ≥ 0 mL/day

Clinical context

In Sepsis-3, an acute SOFA increase of ≥2 points in a patient with suspected infection is used in the clinical definition of sepsis. SOFA-1 does not by itself diagnose sepsis and is not an individual mortality prediction. Interpret the score in clinical context.