Why this matters for ICU/anesthesia? Critical care patients often receive continuous infusions or high doses of drugs (for sedation, analgesia, hemodynamic support, etc.), and organ dysfunction or extracorporeal support can alter drug clearance. Understanding whether a drug’s elimination is linear (dose-proportional) or prone to saturation is crucial. Saturable (non-linear) kinetics can lead to unexpected drug accumulation, necessitating closer monitoring or dose adjustments.

Comprehensive clinical guide to therapeutic plasma exchange (TPE), covering indications, modality selection, dosing strategies, replacement fluids, anticoagulation, monitoring, and complication management across critical care settings.